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SPARKNET Bibliography

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Author and Title Valcke, Y., and Van Der Straeten, M. (1992) Changes in Lymphocyte Subpopulations in Patients Treated with Cefodizime for Acute Lower Respiratory Tract Infections.
Article in Infection, 20 (Supp1), S58.
Available online at
End use
Energy technology
Issue Acute Lower Respiratory Illness, Treatment/Intervention
Level Research
Description The influence of cefodizime (CDZ) on CD4 and CD8 lymphocytes was investigated in patients with ALRI and underlying respiratory diseases. Ten men aand one woman were treated with CDZ for ten days. No adverse events were reported. Nine patients were clinically cured. Two required further antibiotic therapy. Leucocyte counts decreased significantly during treatment. Lymphocyte counts and CD4 cells both increased significantly in absolute and relative numbers. This resulted in an increase in CD4/CD8 ratio. These effects of CDZ may be of benefit for immunocompromised patients with bacterial infections.

This bibliography item comes from the "Broad-search Annotated Bibliography on Acute Respiratory Infections (ARI) and Indoor Air Pollution (With Emphasis on Children Under Five in Developing Countries)", December 1998, Prepared by Daniel M. Kammen, Gemini Wahhaj, and Maame Yaa Yiadom, under EHP Activity No. 263-CC (with support of USAID). Used with permission.




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